Timisoara Medical Journal
Vincenz-Hospital, Limburg, Germany The sentinel node concept SNC and the sentinel node procedure SNP is crucial to understand the relationship of the primary tumor to its regional lymphatics. The adjuvant radiotherapy to lymphatic basins indicated by the SNP could avoid a systematic lymphadenectomy in sentinel node positive patients. We will present here the concept of sentinel node navigation radiotherapy.
Also we shall present data on the selection of lympatic areas to be included in the clinical target volume CTV in head and neck, breast, apparently localized prostate cancer and Merkell Cell carcinoma patients based on the pattern of lymphatic spread indicated by the SNP. Conformal irradiation techniques for adjuvant radiotherapy of the head and neck, axillary and internal mammary chain IMCinguinal and pelvic lymphatic areas are presented.
Basic data on the lymphatic drainage and involvement of different lymph nodes for head and neck, breast, and prostate cancer as well as Merkel Cell carcinoma patients based on the SNP were used.
For treatment planning and CTV delineation the individual location of lymph nodes in axial CT slices was used. The data obtained using the SNP changed the criteria of selection of different lymphatic basins to be included in the CTV in a significant manner.
In Merkel Cell carcinoma patients the SNP is the only available method to describe the individual lymphatic basin and to adapt the optimal treatment strategy.
The conventional irradiation techniques for lymphatic areas in the axilla, IMC, groin and pelvis actually in use are not adequate and have side effects.
At our institution new conformal irradiation techniques for lymphatic areas or basins have been developed and are presented here.
Volum 14 Numarul 2, | Srrom
The concept of the sentinel node navigation radiotherapy and the individual selection of lymphatic areas to be included in the CTV based on the SNP were presented. Sparing of organs at risk and homogenous dose coverage of the CTV using the proposed irradiation techniques is possible. Methods: The crude, age-specific and directly age-standardized prostatită cronică sau nu and mortality rates for GU cancers in Romania were calculated.
Complications from prostate cancer can arise when it metastasizes. Complicațiile de cancer de prostată pot apărea atunci când acesta metastazează. Possible prostate cancer came into the E. Un posibil cancer de prostata a ajuns în U. Scientists have identified several inherited genes that seem to increase prostate cancer risk.
Time trend of the incidence and mortality was assessed by the percent change between and Results: Although in Romania, incidence and mortality rates of GU cancers are lower than in western countries, there was a general increase in the incidence and mortality during the registered period. For urological cancers, the increase concerned both sexes, though incidence and mortality rates in women remained significantly lower than in men.
From large-scale surgery, whose only reason was the safety excision of the tumor, gradually developed a new current, the multidisciplinary treatment for colorectal cancer. Nowadays the main idea is of radical intervention but associated with a good quality of life, idea of radical intervention in terms of a closer to normal functionality.
Conclusions: Our data support that the application of available knowledge on prevention, diagnosis and treatment of these cancers could define a strategy to reduce during the following years the impact of the ascending course of incidence and mortality through GU cancers in Romania.
Results: 32 patients received prior adjuvant treatment 5FU based in both groups, 7 stage II at diagnosis and 25 stage III at diagnosis; 41 patients from both groups received no prior chemotherapy stage IV disease before enrollment.
Both regimens proved to be active; 4 Except for one death by myocardial infarction possibly related to Capecitabine therapy, toxicity was mild, with very few grade three events. Median follow-up was 12 months, range Median overall survival was Conclusion: Both regimens proved active in metastatic setting, with moderate toxicity and increased compliance from patients.
Surgery was planned weeks after the completion of radiochemotherapy. The pathological specimen was evaluated for primary tumor, number of examined lymph nodes and resection margins.
The compliance and toxicity of the concomitant preoperative treatment, and complications after surgery were recorded.
The pathological response rate pCR was complete in The grade 3 toxicity was mainly hematological No grade 4 toxicity was registered. Conclusions: Concomitent preoperative radiochemotherapy with Capecitabine in patients with locally advanced rectal adenocarcinoma has a strong rational support: efficacy, favorable safety profile and moderate toxicity.
The oral chemotherapy i. Key words: Colorectal Cancer, Adjuvant Treatment. Bisphosphonates BP represent an important method of their treatment. Purpose: prostate cancer complications after surgery evaluate the efficiency and toxicity of different type apollo cu prostatita BP in terms of the incidence of skeletal events, the time to the first skeletal- related event and the incidence and severity of adverse effects.
The median age of the patients was 66 years. At least three cycles of BP were administered, half of them being with zoledronic acid.
The median time until the first event was 17 months 22 for Zometa vs. None of the patients underwent bone surgery.
Radicalness versus functionality in colorectal oncologic surgery
Severe toxicity resulted in osteonecrosis of the mandible 1case and kidney failure 1 case. The other adverse effects included arthralgia, myalgia, temporary exacerbation of bone pain and gastrointestinal adverse reactions. Conclusions: Zoledronic acid seems to be more effective in treating bone metastases since it reduces the incidence of skeletal events and increases the time interval until the first skeletal related event, compared to Aredia or Clodronate.
Key words: Bisphosphonates, Prostate Cancer.
- -- Как замечательно.
- prostate cancer - Translation into Romanian - examples English | Reverso Context
Its diagnosis is difficult and very often late because the lesion originates in the submucosa of the stomach wall endoscope biopsy is often inconclusive and also because of the unspecific clinical manifestations even with distant metastasis absence of carcinoid syndrome. The proper therapeutic attitude includes removal of the tumour surgically or endoscopically along with complementary chemotherapy, depending on the carcinoid type, size of the lesion and disease stage.
We hereby give our personal experience with regard to the problems of diagnostic and classification prostate cancer complications after surgery the type of patients diagnosed with gastric malignant carcinoids in our survey.
This paper also presents particularities of surgical and complementary treatment and of prostate cancer complications after surgery postoperative outcome.
Small molecule tyrosine kinase inhibitors may change the outlook in these patients. We present the case of a 62 year old female who was diagnosed in March with chronic phase, Philadelphia positive CML. She was initially treated with hydroxyurea with the achievement of a prostate cancer complications after surgery haematological response CHR but in July the patient progressed to blastic phase.
Subsequently, the patient was started on dasatinib 2 x 70mg daily gaining the achievement of CHR after one month.
Major cytogenetically remission was obtained in 3 months and complete cytogenetically remission CCR in 6 months. This case report underscores the progress being made in recent years in the treatment of CML, even in advanced phases, due to the introduction of tyrosine kinase inhibitors.